Reference entry · Lipidated signal pentapeptide
Palmitoyl Pentapeptide-4
Also known as: Matrixyl · Pal-KTTKS · palmitoyl pentapeptide
- Class
- Lipidated signal pentapeptide
- Size
- 5 amino acids + palmitoyl
- Primary targets (literature)
- Extracellular matrix; collagen synthesis literature
- Regulatory context
- Cosmetic ingredient (Matrixyl) — not FDA-approved as an injectable drug. Lipopeptide catalog material needs palmitoyl-group confirmation.
Overview
Palmitoyl pentapeptide-4 (Matrixyl) is a palmitoylated KTTKS-related pentapeptide studied extensively in cosmetic collagen-stimulation research. Lipidation chemistry requires MS verification beyond simple pentapeptide mass.
Mechanism in research literature
Literature describes stimulation of collagen I and III synthesis in fibroblast models and matrix remodeling in topical application research — distinct from neuromuscular cosmetic peptides.
Common research focus areas
- Fibroblast collagen expression assays
- Palmitoylation and lipopeptide identity testing
- Matrixyl vs. free pentapeptide comparison
- Topical formulation stability research
Full literature roundup
Read the cited research summary
The Matrixyl lipopeptide studied in collagen-stimulation cosmetic research. Fibroblast literature, palmitoylation chemistry, and lipopeptide QC.
Palmitoyl Pentapeptide-4 research roundup · 6 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.