Reference entry · CNTF-mimetic synthetic peptide
P21
Also known as: P21 peptide · CNTF-derived peptide · Peptide 21
- Class
- CNTF-mimetic synthetic peptide
- Primary targets (literature)
- CNTF receptor signaling; neurogenesis literature
- Regulatory context
- Not FDA-approved. Investigational neuropeptide research material with preclinical-only human evidence.
Overview
P21 is a synthetic peptide derived from ciliary neurotrophic factor (CNTF) sequence logic, studied in preclinical models of neurogenesis and cognitive recovery after brain injury. Catalog naming overlaps with unrelated cell-cycle terminology — sequence confirmation is essential.
Mechanism in research literature
Literature describes CNTF receptor engagement and downstream STAT3/survival signaling in neuronal cultures and rodent injury models, with reported effects on hippocampal neurogenesis markers.
Common research focus areas
- Traumatic brain injury and neurogenesis rodent models
- CNTF receptor pathway assays
- Distinction from unrelated 'P21' nomenclature in cell biology
- Peptide identity and endotoxin screening for culture work
Full literature roundup
Read the cited research summary
A CNTF-derived synthetic peptide studied for neurogenesis in brain-injury models. Preclinical literature, naming pitfalls, and material verification for research supply.
P21 research roundup · 7 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.