Reference entry · Mitochondrial-derived peptide
MOTS-c
Also known as: Mitochondrial open reading frame of the 12S rRNA-c
- Class
- Mitochondrial-derived peptide
- Size
- 16 amino acids
- Primary targets (literature)
- Nuclear genome stress response; AMPK pathway literature
- Regulatory context
- Not FDA-approved. MOTS-c catalog material is synthetic RUO peptide, not endogenous mitochondrial translation product.
Overview
MOTS-c is a 16-residue peptide encoded within mitochondrial 12S rRNA, studied for metabolic regulation and exercise-mimetic effects in rodent models. Endogenous production and exogenous supply are distinct research contexts.
Mechanism in research literature
Published work describes nuclear translocation under stress, AMPK pathway engagement, and improved glucose handling in aging and exercise-mimetic rodent paradigms.
Common research focus areas
- Exercise-mimetic metabolic endpoints in mice
- AMPK and folate–methionine pathway crosstalk
- Mitochondrial ORF expression vs. synthetic supply
- 16-mer sequence and purity analytics
Full literature roundup
Read the cited research summary
A mitochondrial-derived 16-mer studied for metabolic regulation and exercise-mimetic effects in rodents. What the ORF literature describes — and how synthetic catalog supply differs from endogenous peptide.
MOTS-c research roundup · 7 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.