Reference entry · Mitochondrial-derived peptide
Humanin
Also known as: HN · mitochondrial-derived cytoprotective peptide
- Class
- Mitochondrial-derived peptide
- Size
- 24 amino acids
- Primary targets (literature)
- Bax, IGFBP-3, inflammatory signaling (literature)
- Regulatory context
- Not FDA-approved. Analog forms sold in catalogs require explicit sequence specification per batch.
Overview
Humanin is a 24-amino-acid peptide first identified in surviving neurons of Alzheimer's disease tissue. It is studied for cytoprotective, metabolic, and inflammatory endpoints across mitochondrial peptide research.
Mechanism in research literature
Literature proposes interference with pro-apoptotic Bax signaling, IGFBP-3 interactions, and inflammatory pathway modulation in cell and animal stress models.
Common research focus areas
- Neuroprotective stress assays in vitro
- Metabolic and insulin-sensitivity rodent models
- Humanin analogs (S14G-HN, etc.) vs. parent sequence
- 24-mer identity and degradation profiling
Full literature roundup
Read the cited research summary
A 24-amino-acid mitochondrial peptide first identified in surviving Alzheimer's disease neurons. What cytoprotective and metabolic literature reports — and where clinical evidence ends.
Humanin research roundup · 7 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.