Reference entry · Endogenous nonapeptide
DSIP
Also known as: Delta sleep-inducing peptide · Δ-SIP
- Class
- Endogenous nonapeptide
- Size
- 9 amino acids
- Primary targets (literature)
- Sleep architecture; HPA/stress-axis literature (mechanism unsettled)
- Regulatory context
- Not FDA-approved. Historical human studies do not establish safety or efficacy for catalog research material.
Overview
DSIP is a nine-residue peptide originally isolated from rabbit brain and associated with sleep-induction research dating to the 1970s. Human and animal studies report mixed, often modest effects on sleep and stress biomarkers — with replication gaps across decades.
Mechanism in research literature
Proposed mechanisms span GABAergic modulation, hypothalamic-pituitary-adrenal axis effects, and circadian timing — without a single dominant receptor target established across independent laboratories.
Common research focus areas
- Polysomnography and sleep-stage endpoints
- Stress-hormone and HPA-axis biomarker studies
- Plasma stability and short half-life pharmacology
- Catalog purity for nonapeptide supply
Full literature roundup
Read the cited research summary
A nine-residue peptide linked to sleep-architecture research since the 1970s. Mixed human and animal data, unsettled mechanism, and what catalog supply requires.
DSIP research roundup · 7 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.