Reference entry · Endogenous neuropeptide (37 amino acids)
CGRP
Also known as: Calcitonin gene-related peptide · α-CGRP · β-CGRP
- Class
- Endogenous neuropeptide (37 amino acids)
- Size
- 37 amino acids (α-CGRP isoform)
- Primary targets (literature)
- CGRP receptor (CALCRL + RAMP1 complex)
- Regulatory context
- Native CGRP is not an FDA-approved standalone drug; anti-CGRP biologics and gepants are approved migraine therapeutics targeting CGRP pathway biology.
Overview
CGRP is a sensory neuropeptide central to migraine pathophysiology research and the target of multiple approved therapeutics. Native α-CGRP and β-CGRP isoforms differ by three residues — catalog material must specify which sequence is supplied.
Mechanism in research literature
CGRP receptor activation promotes vasodilation, neurogenic inflammation, and nociceptive signaling in trigeminovascular research models — forming the mechanistic basis for anti-CGRP monoclonal antibody development.
Common research focus areas
- Trigeminovascular system and migraine models
- α-CGRP vs. β-CGRP isoform distinction
- CGRP receptor antagonist and antibody comparator studies
- 37-mer peptide identity and disulfide-bridge integrity
Full literature roundup
Read the cited research summary
A sensory neuropeptide central to migraine pathophysiology and modern drug development. Isoforms, receptor biology, approved therapeutics, and native peptide supply.
CGRP research roundup · 7 minEvaluate catalog material
- COA literacy — read batch documentation before comparing vendors.
- Peptide identity testing — why sequence confirmation matters beyond purity %.
- How we vet sources — our score methodology for recommended vendors.